1795 results
Approach to Von Willebrand disease (VWD)

By Matthew Ho, MD PhD @MatthewHoMD

#VWD #Von #Willebrand #VonWillebrand #disease #hematology
Von Willebrand disease ... (VWD) By Matthew ... MatthewHoMD #VWD ... VonWillebrand #disease
Platelet disorders and Aggregometry
Glanzmann Thrombasthenia
 • Defective aggregation to all agonists except ristocetin
 • Normal platelet,
also be seen in vWD ... differentiate vWD ... BS by measuring vWF ... Von Willebrand Disease
Hemoptysis - Differential Diagnosis Framework
Massive Hemoptysis: >150-300 mL in 24h
Airway disease: 
 • Bronchitis, Bronchiectasis, Malignancy
in 24h Airway disease ... Coagulopathy: DIC, vWD
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Bone marrow disease ... deficiency • Liver disease ... Von Willebrand disease ... (VWD) • Hypercoagulable ... Dermatosis: Schamberg Disease
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
• Heavy Chain disease ... angioedema • vWD ... Sneddon-Wilkinson disease
Bleeding manifestations 
Petechiae are small, flat, red, discrete areas of skin bleeding that are typically <2
Diagnosis VWF ... (Quantity of VWF ... considered to be low) VWF ... of this plasma VWF ... (differentiate VWD
Acquired von Willebrand Syndrome - Diagnosis and Management
 • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
Autoantibodies to vWF ... thrombocythemia), Autoimmune disease ... • vWF adsorption
Patch dehiscence (post surgical correction of congenital VSD) on Echocardiogram

Ivan Stankovic, MD, PhD @Ivan_Echocardio

#VSD #Patch #dehiscence
of congenital VSD ... Ivan_Echocardio #VSD
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Hemochromatosis, Wilson's Disease ... Syndrome, Celiac Disease ... , Infiltrative Disease ... , Sickle Cell, VOD
Cardiac Auscultation Maneuvers for Murmurs
Maneuvers result in INCREASED murmur:
 • Inspiration - Right-sided
 • Valsalva -
regurgitation, VSD ... regurgitation, VSD