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diagnosis liver algorithm lfts transaminitis management causes acute druginduced alcoholic cirrhosis function gastroenterology hepatocellular interpretation liverinjury tests aclf aflp arterial
Drug-Induced Liver Injury - Pathophysiology Indirect Idiosyncratic Direct BWH Medicine Chiefs @BrighamChiefs #DILI #DrugInduced #Liver #Injury #Pathophysiology #hepatology
Drug-Induced Liver Injury ... - Pathophysiology ... BrighamChiefs #DILI ... #Pathophysiology ... #hepatology
Drugs and Classes Associated with DILI and Type of Liver Injury #Medications #Differential #DrugInduced #LiverInjury #Hepatology #Pharmacology
Associated with DILI ... Type of Liver Injury ... #Medications #Differential ... #LiverInjury #Hepatology ... Pharmacology #Causes #DILI
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 Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Drug-induced Liver Injury ... dose dependent injury ... Calculate R-Value ... Idiosyncratic #differential ... gastroenterology #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - Differential ... Chronic Viral Hepatitis ... (>1000): • DILI ... Drug-induced liver injury ... #Diagnosis #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Induced Liver Injury ... ascites), Chronic hepatitis ... • Autoimmune hepatitis ... #Liver #Injury ... Diagnosis #Algorithm #hepatology
Causes of Severe Acute Liver Injury - Ichemic hepatitis - Acute biliary obstruction - Drug-Induced liver
Severe Acute Liver Injury ... - Ichemic hepatitis ... Drug-Induced liver injury ... Acute #Causes #Differential ... #Hepatology #Diagnosis
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
Transaminitis - Differential ... • Autoimmune hepatitis ... • Iatrogenic: DILI ... #Differential # ... Diagnosis #causes #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Alcohol-Associated Hepatitis ... Drug-Induced Liver Injury ... (DILI) Viral Hepatitis ... Failure #Cirrhosis #Hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... • Iatrogenic: DILI ... Chronic viral hepatitis ... #hepatitis #differential ... diagnosis #algorithm #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver Injury ... , Toxic Hepatitis ... Patterns #Liver #Injury ... #hepatology #LFTs ... transaminitis #differential
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