5 results
Clinical diagnosis of Alcoholic Hepatitis (AH)
 • Onset of jaundice within prior 8 weeks
 • Ongoing
Hepatitis (AH) ... >1.5, and both values ... • Serum total bilirubin ... Possible drug-induced ... #hepatology #criteria
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Idiosyncratic Drug-induced ... Chronic - ongoing ↑ LFTs ... Calculate R-Value ... #DILI #Drug #induced ... #hepatology
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
Phosphatase and Bilirubin ... synthesis, not reduced ... initial insult Bilirubin ... #Hepatology #Pathophysiology ... #Diagnosis #LFTs
Clinical Diagnosis of Autoimmune Hepatitis
 - Onset of jaundice within prior 8 weeks
 - Ongoing consumption
or 60 (male) g alcohol ... >1.5, and both values ... - Serum total bilirubin ... Possible drug-induced ... Hepatitis #Diagnosis #Hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs ... R-value: Serum ... ALT Ratios: • Alcoholic ... #differential #Hepatology ... transaminitis #LFTs