8 results
Primary Biliary Cirrhosis - Diagnosis Algorithm
Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort
Signs: Jaundice, Xanthelasmata, Hepatomegaly
Associated history:
Primary Biliary ... Diagnosis Algorithm Symptoms ... of associated autoimmune ... Liver biopsy findings ... #Biliary #Cirrhosis
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
HELLP - Grafts, Valves ... Membrane): - Autoimmune ... Defects, Drugs, Liver ... Hypophostphatemia Laboratory ... Differential #Diagnosis #hematology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Pathophysiology ... Signs and Symptoms ... or higher • Liver ... cholangitis #diagnosis #workup ... #hepatology
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
Autoimmune Hepatitis ... disease to acute liver ... - Symptoms of ... been reported (eg AIH-PBC ... Necrosis) If mild laboratory
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... • Ischemia • Autoimmune ... • Drugs • AIH ... Bile Ducts • PSC ... Duct Stone • Biliary
Clinical Diagnosis of Autoimmune Hepatitis
 - Onset of jaundice within prior 8 weeks
 - Ongoing consumption
Clinical Diagnosis of Autoimmune ... >1.5, and both values ... ) or metabolic liver ... Presence of atypical laboratory ... #AIH
Systemic Sclerosis (Scleroderma)
Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs
3
Multi-system autoimmune ... pericarditis • Hepatic: PBC ... (primary biliary ... diagnosis #signs #symptoms ... #testing #workup
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
and fever) and laboratory ... disease • Non-autoimmune ... deficiencies • Autoimmune ... : • AIHA 10% • ... Induced Lupus: • Symptoms