14 results
Primary Adrenal Insufficiency
Addison's Disease - Damage of the adrenal glands with lack of cortisol, androgens and
Nausea/vomiting • Abdominal ... Serum DHEAS Diagnosis ... /dL -> Primary AI ... #endocrinology ... #diagnosis #signs
Adrenal Insufficiency - Diagnosis and Management Summary
Primary Adrenal Insufficiency:
Most Common Cause in the US: Autoimmune Adrenalitis
Other
Cause in the US: Autoimmune ... or metastatic disease ... ) w/ anorexia, abdominal ... A STIM test can ... #Management #Endocrinology
Cold Urticaria
Prevalence - 0.05% in the population
Disease onset - Mostly 2nd to 4th decades of life
Causes
Autoimmune diseases ... contact with cold air ... fatigue, Nausea, abdominal ... Cold #Urticaria #diagnosis ... #rheumatology #
Causes of Adrenal Insufficiency - Differential Diagnosis Algorithm
ACTH-Dependent (Secondary):
 • Pituitary Dysfunction
 • Hypothalamic Dysfunction
ACTH-Independent (Primary):
- Differential Diagnosis ... (Primary): • Autoimmune ... Granulomatous Disease ... Insufficiency #AI ... Algorithm #Causes #endocrinology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
- Differential Diagnosis ... HELLP - Grafts, Valves ... Membrane): - Autoimmune ... Laboratory Tests ... #hematology
Clinical Diagnosis of Autoimmune Hepatitis
 - Onset of jaundice within prior 8 weeks
 - Ongoing consumption
Clinical Diagnosis ... of Autoimmune Hepatitis ... >1.5, and both values ... atypical laboratory tests ... #Hepatology #AIH
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Chain deposition disease ... Atypical HUS, autoimmune ... atheroembolic, AIHA ... CHAMPS #Mnemonic #diagnosis ... #differential #hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
women • 15% of AIHA ... Viral infection, autoimmune ... CLL (older) • Autoimmune ... Test: Donath-Landsteiner ... test #cold #
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
activity - A low value ... hallmark for the disease ... If the value is ... low, tests to detect ... #Workup #Hematology
Cushing's Syndrome - Hypercortisolism - Diagnosis and Clinical Features
1) Skin
 • Thin, easily bruisable skin with
Hypercortisolism - Diagnosis ... classically purple abdominal ... dexamethasone suppression test ... the abdomen for adrenal ... signs #symptoms #endocrinology