11 results
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Diagnosis and Management ... symptoms of liver disease ... Calculate R-Value ... Idiosyncratic #differential ... #Diagnosis #Management
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Diagnosis Framework ... HELLP - Grafts, Valves ... Laboratory Tests ... #Diagnosis #hematology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Liver Injury - Differential ... Diagnosis Algorithm ... • Iatrogenic: DILI ... extrahepatic source - Tests ... #hepatology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
nausea, vomiting, abdominal ... 10x ULN), ↑Tbili/Dbili ... infiltration) Differential ... Diagnosis: Viral ... Liver #Pregnancy #hepatology
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
Positive pathergy test ... is a skin prick test ... ) Differential Diagnosis ... • Nonsurgical abdominal ... #management #signs
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs R-value ... of cholestatic disease ... liver #chemistry #diagnosis ... #differential # ... Hepatology #transaminitis
Ascites - Diagnostic Approach and Differential Diagnosis
The most common causes: cirrhosis, malignancy and heart failure. Approx
auscultatory percussion, abdominal ... of underlying disease ... bilirubin 2) Routine tests ... 3) Optional tests ... #Diagnosis #hepatology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
activity - A low value ... hallmark for the disease ... If the value is ... low, tests to detect ... WBC count and differential
Polycythemia - Differential Diagnosis Algorithm
Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Polycythemia - Differential ... that a one-off value ... can drive this disease ... As with many disease ... Best to have an
Preoperative Risk Evaluation

Major Pre-Op Questions:
1. Does the patient have any modifiable risk factors that could be
determine if stress test ... one post op Cardiology ... undergoing AAA or upper abdominal ... medical and surgical management ... stratification #diagnosis