7 results
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓)
of cytochrome p450 CYP3A4 and P-glycoprotein.

DOACs are substrates
thereby leading ... metabolization leading ... #Chemotherapy #Oncology ... #Hematology #Interactions ... #Table #Pharmacology
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis.

Currently, edoxaban and rivaroxaban are the only
anticoagulants (DOACs ... filtration rate; DOAC ... Cancer #Algorithm #Anticoagulation ... #Management #Hematology ... #Oncology
Perioperative Management of DOACs
Problem:
 ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
patients on chronic anticoagulation ... per treatment table ... and procedural bleeding ... with a very low bleeding ... may not require anticoagulation
Treatment algorithm for VTE in Malignancy

(A) Suggested treatment algorithm for symptomatic and incidental DVT or PE
DOAC, direct oral ... #DOAC #VTE #Malignancy ... Cancer #Algorithm #Anticoagulation ... #Management #Hematology ... #Oncology
Managing warfarin INR

Warfarin dosage must be individualized according to the patient's response to the drug, and
Over-anticoagulation ... lead to severe bleeding ... #medications #table ... decisionaid #cardiology #hematology
Peripartum Cardiomyopathy - Summary
1. Definition
 • Towards the end of pregnancy to 5 months postpartum
Avoid Warfarin and DOAC ... during Delivery • Stable ... Period • Breast-feeding ... suggest prophylactic anticoagulation
Bleeding Risk for Various Invasive/Surgical Procedures
Low Risk:
 • Dental extractions (1 or 2 teeth), endodontic (root
Bleeding Risk for ... Cataract surgery • Dermatologic ... placement (if bridging anticoagulation ... polypectomy) #Bleeding ... Perioperative #Procedures #Table