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diagnosis causes leukemia approach classification cll diffuse infections infectiousdiseases isolated lad lymphadenopathy lymphocytic management mds mycobacteria myelodysplasia myelodysplastic nontuberculous normocytic
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
Causes of Neutropenia ... Diagnosis Algorithm ... • Toxins • Aplastic ... Anemia • Myelodysplasia ... #Differential #
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... Presentation: • Fever • Fatigue ... #Anemia #oncology ... #hematology #diagnosis
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
- Differential ... Diagnosis Algorithm ... Neoplastic / Hematologic ... • Anemia • ... #Chronic #Fatigue
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
- Differential ... Diagnosis Algorithm ... Deficiency • Aplastic ... of Chronic Disease ... #Causes #Hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Volume (MCV) - Differential ... Diagnosis Algorithm ... • Marrow Aplasia ... RA, SLE, PRV, Chronic ... #Causes #Hematology
Causes of Isolated Neutropenia - Differential Diagnosis Algorithm Congenital Medications • Anticonvulsants • Antibiotics • Antithyroid • Antihypertensive
- Differential ... Diagnosis Algorithm ... • Epstein-Barr Virus ... Idiopathic - Chronic ... #Causes #Hematology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Diagnosis Algorithm ... Bleeding, Infection, Fatigue ... Age > 50 • Chronic ... #Causes #Hematology ... #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
sweats • Extreme fatigue ... Cytopenias: • Neutropenia ... , anemia, thrombocytopenia ... Pure red cell aplasia ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
CML Symptoms: • Fatigue ... - infiltrates (anemia ... or functional neutropenia ... #Leukemia #Hematology ... #Oncology #Diagnosis
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Symptoms: • Fatigue ... • Aplastic Anemia ... Marrow Failure • Chronic ... blood count with differential ... #oncology
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