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diagnosis differential workup management aplastic classification hemolytic hodgkins lymphoma platelets testing thrombocytosis
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Pancytopenia - Differential ... deficiency • Fanconi’s anemia ... Antibody-mediated hemolysis ... • Epstein-Barr virus ... Differential #Diagnosis #Hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Differential Diagnosis Algorithm ... Acquired Aplastic Anemia ... Non-Nutritional - Malignancy ... hematological Malignancy ... #Hematology
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Differential Diagnosis Algorithm ... Acquired Aplastic Anemia ... Non-Nutritional - Malignancy ... hematological Malignancy ... #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
concerning for malignancy ... → Refer to hematology ... blood loss, Acute hemolysis ... , deficiency anemia ... #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Differential Diagnosis Algorithm ... valve, vasculitis, malignant ... #Anemia #Differential ... #workup #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
bone marrow + pancytopenia ... immunodeficiency virus ... • Epstein-Barr virus ... • Peripheral Pancytopenia ... #oncology #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
hematological malignancy ... nodosum • Immune hemolytic ... anemia • Pain ... classification #hematology ... #oncology #management
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