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diagnosis management rheumatology druginduced sle summary treatment apls bcnie bloodculture comparison complications ddxof differential dil endocarditis erythematosus hemophagocytic hlh hypercoagulable
Algorithm for the Evaluation and Management of Sickle Cell Crises Clinical Manifestations and Management #Diagnosis #Management #Hematology #SickleCell
Evaluation and ... of Sickle Cell Crises ... Clinical Manifestations ... Diagnosis #Management #Hematology ... Manifestations #Workup
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
40, F:M 9:1 • Clinical ... • Immunologic Workup ... Positive in 60-80% of cases ... management of SLE • Evolution ... : Chronic disease
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... • Immunologic Workup ... 40, F:M 9:1 • Clinical ... • Immunologic Workup ... : Chronic disease
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Assessment • Clinical ... Infections+++: Virus ... • Autoimmune diseases ... inhibitors under evaluation
Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm INDICATIONS FOR TESTING: • Vascular thrombosis
Antiphospholipid ... - 1 or more clinical ... maternal chromosomal causes ... excluded Testing: • Lupus ... #hematology
Blood Culture-Negative Infective Endocarditis (BCNIE) Definition: No etiology found after 3 separate blood cultures remain negative for
BCNIE relies on evaluation ... antimicrobials, clinical ... but important causes ... rheumatoid factor, antiphospholipid ... exists Infectious Diseases
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
to 1:1 F:M • Clinical ... • Immunologic Workup ... Discontinuation of causal ... cutaneous-DIL • Evolution ... #DIL #rheumatology
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