48 results
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
) - HELLP syndrome ... uremic syndrome ... spherocytosis) • Infections ... Extravascular #Causes #differential ... #diagnosis #hematology
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
Wiskott-Aldrich syndrome ... Antibody-mediated hemolysis ... deficiency Infections ... • Epstein-Barr virus ... #Diagnosis #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
Platelet Count - Differential ... blood loss, Acute hemolysis ... Rebound effect from treatment ... Inflammatory Conditions: Rheumatologic ... Kawasaki, Nephrotic syndrome
BEE Syndromes - Non-inflammatory Causes

Immune-mediated conditions affecting the Brain, Eye, and Ear

Visual or auditory symptoms in
diagnosis and treatment ... • Herpes virus ... infections • ... #neurology #noninflammatory ... #differential #
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Drug-associated, PCH, Evans Syndrome ... Internal (RBC) - Infections ... #Differential # ... Diagnosis #hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cold Agglutinin Syndrome ... - Due to Viral infection ... Diagnosis: • hemolytic ... younger pts) Differential ... #anemia #hematology
Causes of Sore Throat / Rhinorrhea - Differential Diagnosis Algorithm
Common viral pathogens: Rhinovirus, Coronavirus, Influenza virus,
/ Rhinorrhea - Differential ... : Group A Beta Hemolytic ... Acute Head Cold Syndrome ... Tracheobronchitis • Acute Infectious ... SoreThroat #Rhinorrhea #Differential
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 • Acute infection
 • Solid organ
Thrombocytosis - Differential ... Thrombocytosis): • Acute infection ... iron deficiency, hemolysis ... Myelodysplastic syndrome ... Diagnosis #Causes #hematology
Hematuria in Post-Renal Transplant Patient
Prevalence up to 12% in the postrenal transplant patient
 • Bacterial: Escherichia
: Secondary to infections ... (Goodpasture's syndrome ... Renal #Transplant #differential ... urine #management #treatment ... #nephrology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... +++: Virus (EBV, ... Unknown cause Treatment ... diagnosis #management #treatment ... #summary #rheumatology