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diagnosis differential hematology causes extravascular hemolysis agglutinin anemias cold disease mcv nonpalpable pancytopenia petechiae petechial purpural purpuric testing workup
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... idiopathic) - Autoimmune ... spherocytosis) • Infections ... #Hemolytic #Intravascular ... #anemia
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... Hemolytic Anemias ... Hemolytic Anemias ... Hypersplenism, Infection ... #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Diagnosis Algorithm ... Cold AIHA • Alloimmune ... circulation - Infections ... anemia • ... #Causes #Hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
Algorithmic Approach ... , CKD • Hemolytic ... - Extrinsic: Autoimmune ... Macroangiopathic, Infections ... #MCV #Algorithm
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
deficiency • Fanconi’s anemia ... Inflammatory and Autoimmune ... Antibody-mediated hemolysis ... deficiency Infections ... • Epstein-Barr virus
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Differential Diagnosis Algorithm ... inclusions - If infection ... elliptocytosis, autoimmune ... #workup #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
, autoimmune disorder ... anemia • Cold ... CLL (older) • Autoimmune ... the RBCs causing intravascular ... #anemia #hematology
Petechial/Purpuric Rashes- THE ALGORITHMIC APPROACH These rashes can be especially challenging and are associated with devastating differential
inflammation or infection ... , disseminated intravascular ... vasculitis, such as autoimmune ... #Diagnosis #Dermatology ... Purpural #Purpuric #Rash
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