13 results
REBEL Review 99: Serotonin Syndrome via Yosuf Alam, MSIV

Presentation: Altered mentd status, Seizures, Myoclonus, Hypertension, Hyperthermia
Hyperthermia (most common cause ... Cornerstone of treatment ... all serotonergic drugs ... SerotoninSyndrome #management ... #toxicology #REBELEM
Vancomycin Associated Acute Kidney Injury

 • Drug induced acute kidney injury is generally defined as a
Kidney Injury • Drug ... • Treatment includes ... Vancomycin #AKI #pharmacology ... #toxicology #diagnosis ... #management #nephrology
Fever vs Hyperthermia
Fever:
 • Regulated in the hypothalamic thermoregulatory center
 • "Set point" raised by prostaglandin
production • Treatment ... : Drugs: Ecstasy ... #Hyperthermia #comparison ... #diagnosis #management ... #treatment
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Infections+++: Virus ... immune deficiency, Drugs ... Treatment: • Etiological ... #management #treatment ... #summary #rheumatology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
life-threatening • Treatment ... Usual therapeutic management ... druginduced #lupus #sle #comparison ... #table #rheumatology ... #diagnosis #management
Clozapine Toxicology
Clozapine is an atypical antipsychotic most often reserved for use in patients who have treatment-resistant
patients who have treatment-resistant ... antipsychotic drugs ... Clozapine is known to cause ... #Toxicity #Diagnosis ... #Pharmacology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
and petechiae Causes ... Dyskeratosis congenita • Drugs ... - Cytotoxic drugs ... aplastic anemia Treatment ... #diagnosis #management
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS

What Is IRIS?
	• A state of hyperinflammatory response that
superinfection, drug ... unintentional weight loss, nausea ... : • Drug reaction ... active infection/drug ... #Management
Drug Induced Lupus (DIL)
 • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
constitutional symptoms • Treatment ... Discontinuation of causal ... DrugInduced #Lupus #DIL #rheumatology ... #diagnosis #treatment ... #management
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... Adenocarcinoma Treatment ... lubricants • Pharmacologic ... Sjogrens #Syndrome #Rheumatology ... #Diagnosis #Management