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diagnosis management hematology neurology disorders oncology syndromes apml arthritis barre bee cardiology chf classification clinical comatose criticalcare differentiation eosinophil eosinophilia
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Disorders Testing Algorithm ... glucocorticoid treatment ... organ-specific signs ... #Differential # ... diagnosis #hematology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... high WBC count cause ... WBC >100k, + lab signs ... : • Pathophysiology ... diagnosis #management #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... Drugs, Unknown cause ... Treatment: • ... of emergency, ICU ... #summary #rheumatology
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
life-threatening Differential ... : - Bedside: ice ... test - Cogan sign ... - Peek sign ... immunologic assay - MuSK
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Diagnosis Algorithm ... Amy Chung, MD, MSc ... Classification #pathophysiology ... #Hematology #Diagnosis ... #algorithm
BEE Syndromes - Non-inflammatory Causes Immune-mediated conditions affecting the Brain, Eye, and Ear Visual or auditory symptoms in
Non-inflammatory Causes ... diagnosis and treatment ... Non-inflammatory causes ... consistent with MS ... noninflammatory #differential
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Pathophysiology ... initiation • Differential ... organ dysfuxtion, ICU
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
Pain - Arthritis Differential ... noninflammatory Signs ... weeks) Can Be Caused ... #Diagnosis #MSK ... #rheumatology #
Guillain-Barré Syndrome (GBS) Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness Epidemiology: • Incidence: 1
Guillain-Barré Syndrome ... Incidence: 1 to 2 cases ... the underlying pathophysiology ... and cauda equina TREATMENT ... intensive care unit (ICU
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Out Secondary Causes ... Significance (ICUS ... factor (GCSF) treatments ... blood count with differential ... #diagnosis #hematology
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