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differential anemia causes classification workup oncology thrombocytosis atlas elevatedmcv macrocytic macrocytosis mcv microcytic morphology rbc secondary aml approach basophilia basophils
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
lymphoproliferative disorder ... Diagnosis: • hemolytic ... Immunoglobulin M (IgM) • Blood ... sensitize red blood ... #anemia #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... . primary cold agglutin ... lymphoproliferative disorders ... #differential #diagnosis ... #hematology #anemia
Map of proliferative blood disorders. By Ariella Coler-Reilly @ariellastudies #Algorithm #classification #proliferative #blood #disorders #leukemia #hematology #oncology
proliferative blood ... disorders. ... ariellastudies #Algorithm ... #hematology #oncology ... #diagnosis #CML
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential Diagnosis ... Algorithm • Sickle ... Agglutination - Cold agglutinins ... Consider RBC membrane disorder ... #hematology #testing
Iron Deficiency Anemia - Differential Diagnosis Algorithm Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR • Blood loss:
- Differential Diagnosis ... Algorithm Labs ... TSAT, sTfR • Blood ... extravascular) hemolysis ... #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
- Differential Diagnosis ... Algorithm Spurious ... • Rheumatic disorders ... malignancy • Iron ... #Hematology
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... High in acute blood ... loss, hemolysis ... (BM) ablative disorders ... #Hematology #Microcytic
Algorithm for workup of thrombocytopenia based on observation of the peripheral blood film. TTP/HUS indicates thrombotic
Algorithm for workup ... the peripheral blood ... thrombocytopenic purpura/hemolytic ... thrombocytopenia, Hematology ... 2012, p 193 #Diagnosis
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
- Differential Diagnosis ... Algorithm Blood ... MCH, MCHC, Serum Iron ... Reticulocytes • Iron ... #Hematology
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
Algorithmic Approach ... - Differential Diagnosis ... inflammation) • Iron ... -100): • Non-hemolytic ... #hematology
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