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Algorithm for the Evaluation and Management of Sickle Cell Crises
Clinical Manifestations and Management

#Diagnosis #Management #Hematology #SickleCell
Evaluation and Management ... of Sickle Cell Crises ... #Diagnosis #Management ... #Hematology #SickleCell ... Manifestations #Workup
Acute Respiratory Distress Syndrome – ARDS: Clinical Cheat Sheet

An acute diffuse, inflammatory lung injury, leading to
leading to increased pulmonary ... vascular permeability ... consistent with pulmonary ... there is no clear cause ... the underlying cause
Causes of Neutrophilia - Increased Neutrophils - Differential Diagnosis Algorithm
Infection
 • Bacterial
 • Abscess
 • Viral
Medications
Causes of Neutrophilia ... Lung, Bladder, Colon ... Polycythemia vera Acute ... Diagnosis #Algorithm #Causes ... #Hematology
Causes of Pleural Effusion - Differential Diagnosis Algorithm
Transudate - Hydrostatic
 • Congestive heart failure
 • Constrictive
Causes of Pleural ... Pneumonectomy • Trapped lung ... embolism • Collagen vascular ... Diagnosis #Algorithm #Hepatology ... #causes
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Etiology: • Vascular ... Disruptions in vascular ... - APLS • Acute ... Differential #Diagnosis #hematology ... #rheumatology #
Hemoptysis - Differential Diagnosis Framework
Massive Hemoptysis: >150-300 mL in 24h
Airway disease: 
 • Bronchitis, Bronchiectasis, Malignancy
Kaposi's sarcoma • Rheumatologic ... Heart failure Vascular ... Postprocedural, Lung ... Differential #Diagnosis #pulmonary ... #causes
Noncardiogenic Pulmonary Edema - Differential Diagnosis Framework

NCPE Pathophysiology:
Noncardiogenic pulmonary edema occurs because of excessive pulmonary capillary
Causes include: ... • A lack of acute ... vascular congestion ... Etiology: • Acute ... lung injury (TRALI
Systemic Sclerosis (Scleroderma)
Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs
3
calcinosis • Pulmonary ... (interstitial lung ... myositis overlap • Vascular ... Scleroderma #SSc #rheumatology ... symptoms #testing #workup
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Diagnosis and Management ... old, ~10,000 new cases ... transformation to acute ... leukemia Management ... #treatment #hematology
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
Causes of Bone/Joint ... Generally affects long ... Avascular necrosis ... differential #diagnosis #causes ... #hematology