32 results
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
Causes of Bone/Joint ... Avascular necrosis ... • Differentiate ... #diagnosis #causes ... #hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Drug induced - Bone ... Kasabach-Merritt syndrome ... #Diagnosis #hematology ... #rheumatology #
SAPHO Syndrome Summary

What?
SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
SAPHO Syndrome Summary ... SAPHO syndrome is ... • Bone and joint ... Rule out other causes ... #Rheumatology #
Vascular Joint Pain - Differential Diagnosis Algorithm 
 - Constant Pain (Ischemia)
 - Acute Onset
 -
Vascular Joint Pain ... - Differential ... fractured long bone ... Marfan's Syndrome ... #Orthopedics #Causes
Approach to Joint Pain - Diagnostic Framework

1) Chronicity
2) Inflammatory vs Non-Inflammatory
3) Number of Joints Involved

1) Chronicity:
Approach to Joint ... Non-bloody: OA, avascular ... Like in this case ... #rheumatology # ... approach #workup #differential
Causes of Thrombocytopenia - Differential Diagnosis Framework
Decreased Production:
 - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Causes of Thrombocytopenia ... - Differential ... folate def - Bone ... antiphospholipid syndrome ... Diagnosis #Framework #hematology
Gout Tophus on POCUS

Linear transducer about 1cm away from bone/joint, typical of small joint in a
Gout Tophus on POCUS ... 1cm away from bone ... tophi #clinical #POCUS ... #ultrasound #msk ... #rheumatology #
Approach to Joint Pain

History:
Is the pain from:
	• Joint
	• Adjacent bursa
	• Tendon
	• Ligament
	• Bone
	• Muscle
	• Referred from
• Ligament • Bone ... the subchondral bone ... osteopetrosis, avascular ... #Pain #MSK #rheumatology ... approach #workup #differential
Shock - Differential Diagnosis Framework
MAP = CO x SVR
Hypovolemic (↓ Intravascular volume):
 • Hemorrhage, dehydration due
Shock - Differential ... findings based on cause ... tone): • Sepsis ... anaphylaxis, release syndrome ... #Diagnosis #table
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Splenic Marginal Zone ... Scleromyxedema (CNS+GI+CVS+joints ... (Thrombosis in vascular ... Paraproteinemias #Hematology ... #Monoclonal #Differential