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differential hematology oncology systemic causes generalized nephrology pancytopenia pruritus secondary antiphospholipid apls chronic cll emergencies erythematosus framework gap globulin hemeonc
Workup for Hypophosphatemia - Differential Diagnosis Framework Rule out spurious hypophosphatemia: paraproteinemia, acute leukemia Measure Urine Fractional Excretion
Workup for Hypophosphatemia ... - Differential Diagnosis ... paraproteinemia, acute leukemia ... FEPO4 ≥ 5% - Renal ... • Normal or Low
Hypernatremia - Differential Diagnosis Workup Algorithm 1) Check Urine Osmolality: > 600 mOsm/kg - Implies extrarenal mechanism
- Differential Diagnosis ... Workup Algorithm ... • Euvolemic (Low ... , Cushing syndrome ... #Workup #Algorithm
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Algorithm - Systemic ... Skin Lesions == Macules ... • Lymphoma • Leukemia ... Myelodisplastic syndrome ... #generalized #dermatology
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Pancytopenia - Workup ... Algorithm Consumption ... Production - Flow ... HLH syndrome 5. ... #Algorithm #Hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
involves face: macules ... CBC • Confirm: Flow ... • Richter’s Syndrome ... • Sezary syndrome ... #diagnosis #workup
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Pancytopenia - Workup ... Algorithm Consumption ... Production - Flow ... HLH syndrome 5 ... #Algorithm #Hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Chronic Myelogenous Leukemia ... • Hairy Cell Leukemia ... Workup: • Complete ... #diagnosis #hematology
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Algorithm Blood ... BUN: • Chronic renal ... • Lymphoma • Leukemia ... Myelodisplastic syndrome ... #generalized #dermatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low ... Erythematous, macular ... Differential Diagnosis ... , lymphopenia, low ... Hodgkin lymphoma and leukemia
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
full infectious work-up ... acid, high LDH, low ... high d-dimer, low ... Usually myeloid leukemias ... Oncology #HemeOnc #Diagnosis
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