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differential management neurology hematology vasculitis agglutinin algorithm ana anemia antibodies antinuclear arthritis classification cord erythematosus hemolytic leukemia lupus manifestations monoarthritis
Neuromyelitis Optica (NMO) - Clinical Manifestations • Optic neuritis: Reduced visual acuity, ranging from mild to
neuritis: Reduced visual ... , Comorbid autoimmune ... disorders (Systemic ... Manifestations #diagnosis ... #neurology #symptoms
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Agglutinin Syndrome ... infection, autoimmune ... - Mycoplasma, EBV ... CLL (older) • Autoimmune ... chills, flank pain
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
context of other symptoms ... , Myositis, Mixed ... Lymphoproliferative Disorders ... ANA #patterns #rheumatology ... #diagnosis #differential
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
Differential Diagnosis ... Mechanical/degenerative disorders ... constitutional symptoms ... Rheumatologic Disease ... #Diagnosis #MSK
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
• Non-autoimmune ... rheumatologic diseases ... pain • Swan neck ... Induced Lupus: • Symptoms ... #Rheumatology
Spinal Cord Disorders - Differential Diagnosis Framework Spinal cord neurological lesion: Clinical findings: • Symptoms and signs below
Spinal Cord Disorders ... - Differential Diagnosis ... Sarcoidosis, Behcet disease ... - SLE, Scleroderma ... MCTD, Sjogren syndrome
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... or without back pain ... Bilateral signs and/or symptoms ... Evaluate for NMO, SLE ... : - SLE - Neurosarcoidosis
Multiple Sclerosis - Summary Multiple Sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system
Sclerosis (MS) is an autoimmune-mediated ... neurodegenerative disease ... • Or brainstem syndromes ... impairment, Mood disorder ... Sensitivity to pain
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... , fever, joint pain ... • Tumor lysis syndrome ... Transformation: • Complication ... #Oncology #Diagnosis
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
, such as SLE, atherosclerotic ... claudication, visual ... tract: Abdominal pain ... • Progressive symptoms ... #Rheumatology
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