15 results
TOPCAT - Spironolactone for Heart Failure with Preserved Ejection Fraction

N Engl J Med 2014; 370:1383-1392 https://www.nejm.org/doi/10.1056/NEJMoa1313731

CONCLUSIONS:
ejection fraction, treatment ... cardiovascular causes ... - Visual Abstract ... dCHF #Cardiology #EBM
Potassium-Binding Agents to Treat Hyperkalemia
Sodium zirconium cyclosilicate (Lokelma):
 • Mechanism: Preferentially captures K in exchange for
Usual maintenance ... constipation, diarrhea, nausea ... ); nausea, vomiting ... #pharmacology #table ... #comparison #binders
Comparison of Fever Algorithms for Infants <3 months old

AGE, INCLUSION, TESTS 
REQUIRED, "LOW RISK" CRITERIA, TREATMENT,
Comparison of Fever ... Algorithms for ... RISK" CRITERIA, TREATMENT ... low-risk criteria #EBM ... #Comparison #Table
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
Management Summary Causes ... - Infection - Viral ... Treatment of underlying ... per day until stable ... Diagnosis #Management #causes
Hyperkalemia - Diagnosis and Management - GrepMed Handbook

S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Weakness, cramping, nausea ... arterial volume (↓distal ... 20 suggests ↓ distal ... only if no clear cause ... Elimination (see Table
A Comparison of Headache Treatment in the Emergency Department: Prochlorperazine Versus Ketamine
Zitek T, Gates M, Pitotti
A Comparison of ... Headache Treatment ... A Comparison of ... Visual Abstract ... dhcisewski #EBM
Rhabdomyolysis - Differential Diagnosis and Management Summary

Trauma:
 • Immobilization, Crush iniury, Compartment syndrome, Electrical injury
Exertional:
 •
ETOH Infection (Viral ... per day until stable ... Dialysis for severe hyperkalemia ... Management #Summary #causes ... #treatment
Randomized Controlled Trial of Intravenous Acetaminophen Versus Intravenous Hydromorphone for the Treatment of Acute Pain in
Hydromorphone for the Treatment ... the cost of more nausea ... and vomiting Visual ... Abstract by David ... dhcisewski #EBM
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... non-essential drug/HDS treatments ... for alternative causes ... Hepatocellular: Viral ... HBV, HCV, HEV, EBV
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Discontinuation of causal ... life-threatening • Treatment ... : Usual therapeutic ... druginduced #lupus #sle #comparison ... #table #rheumatology