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syndrome systemic blood nephrology product reactions scleroderma sclerosis vasculitis workup anesthesia anesthesiology antinxp2 antinxp2dm apml autoantibodies capillary clarksons crisis cryoglobulinemia
Systemic Sclerosis Associated Autoantibodies Anti-topoisomerase I (anti-Sc170): Diffuse skin disease, Pulmonary fibrosis Anti-centromere: Limited skin disease (~93-95%), Pulmonary
skin disease, Pulmonary ... hypertension, Digital ... III: Diffuse, Renal ... Autoantibodies #diagnosis ... #rheumatology
Renal involvement in 35% of mixed cryoglobulinemia vasculitis Associated with : • Absence of skin
Renal involvement ... day - 49% • Hypertension ... TerrierBen #Renal ... Cryoglobulinemia #Vasculitis #Management ... #Rheumatology #
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
calcinosis • Pulmonary ... arterial HTN) • Renal ... : scleroderma renal ... Scleroderma #SSc #rheumatology ... #diagnosis #signs
Intraoperative Hypertension - Guidelines for Crises in Anaesthesia Hypertension is most commonly due to inappropriate depth of
• Visual inspection ... alfentanil can be diagnostic ... drug interaction, renal ... Intraoperative #Checklist ... #Diagnosis #Management
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Imaging: CXR- pulmonary ... opacities • Diagnosis ... • Differential Diagnosis ... Anaphylaxis, Acute Renal ... #management #hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
, INC risk PE, Pulmonary ... (Type I) renal ... Nephrogenic DI Hematologic ... Sjogrens #Syndrome #Rheumatology ... #Diagnosis #Management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... Non-autoimmune rheumatologic ... Frank nephritis (hypertension ... APLA/LAC: • Renal ... #Rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
- Differential Diagnosis ... and renal abnormalities ... Vasculitis Differential Diagnosis ... claudication, visual ... #Rheumatology
Scleroderma Renal Crisis (SRC) Clinical Presentation of Scleroderma Renal Crisis: 1) Acute kidney injury 2) Abrupt onset of hypertension 3)
Abrupt onset of hypertension ... of arteries Management ... #Crisis #rheumatology ... #nephrology #diagnosis ... #management
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
, DIC, hypoTN, renal ... ↑bleeding • Hypotension ... #Transfusion #diagnosis ... #management #hematology
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