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diagnosis hematology differential treatment signs rheumatology algorithm causes neurology gastroenterology cardiology deficiency dermatology nutrition pathophysiology pulmonary disease hepatology infectiousdiseases primary
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Pancytopenia: • ↓ RBC ... • ↓ WBC • ↓ ... • Improve the symptoms ... #oncology #hematology ... #diagnosis #management
Approach to Leukocytosis - Differential Diagnosis Algorithm Features of hematologic malignancy: • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
malignancy: • Symptoms ... : B-symptoms, bruising ... hepatomegaly • Labs: anemia ... platelets, persistent WBC ... Algorithm #hematology #WBC
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell (RBC ... Iron-deficiency anemia ... Myelodysplastic syndrome ... Hemolytic uremic syndrome ... coagulopathy (DIC) #RBC
Oncologic Emergencies - Differential Diagnosis Framework HEMATOLOGIC ONCOLOGIC EMERGENCIES: Hyperviscosity Syndrome: • Spontaneous bleeding • Shortness of breath
Oncologic Emergencies ... Hyperviscosity Syndrome ... Leukostasis: • WBC ... Superior Vena Cava Syndrome ... : Tumor Lysis Syndrome
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... Diagnosis and Management ... cytopenias (usually anemia ... Myelodysplastic #Syndrome ... treatment #hematology #oncology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Neutrophils - Low RBC ... • Pernicious Anemia ... Myelodysplastic Syndromes ... Cells, Normal WBCs
Gastric Neuroendocrine Tumor (NET) Types Type 1 - Chronic atrophic gastritis and pernicious anaemia Type 2 - Zollinger
and pernicious anaemia ... Zollinger Ellison syndrome ... Classification #oncology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Vmphocytosis on routine CBC ... of anemia or thrombocytopenia ... marrow failure with anemia ... Lymphocytic #Leukemia #oncology ... hemeonc #diagnosis #management
Hematology Algorithms Anemia is described as a reduction in the proportion of the red blood cells.
experience some symptoms ... RBC are produced ... Approximately 1% of RBC ... destruction of RBC ... Mentzer index = (MCV/RBC
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
blasts and high WBC ... Dehydration • Symptoms ... changes, stroke symptoms ... • Lab values: WBC ... TLS #diagnosis #management
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