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Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table

Warm AIHA (48-70%)
Cold AHA (16-32%)
 • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Anemia (AIHA) - ... Differential Diagnosis Table ... hemoglobinuria) • Cold Agglutinin ... #Anemia #AIHA #
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... uremic syndrome ... . primary cold agglutin ... • Intrinsic RBC ... diagnosis #hematology #anemia
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Syndrome (CAS): ... • Symptoms of anemia ... anemia • Cold ... Blood smear - RBC ... #anemia #hematology
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
Anemia 1) DIAGNOSE ... AIHA • Anemia ... ↑ LDH • Anti-RBC ... #Anemia #diagnosis ... #management #treatment
Red Blood Cell (RBC) Morphology Atlas
 • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell (RBC ... Myelodysplastic syndrome ... spherocytosis, Hemolytic ... Schistocytes - Hemolytic ... uremic syndrome
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Agglutination - Cold agglutinins ... elliptocytosis, autoimmune hemolysis ... ARUPConsult @ARUPLabs #Hemolytic ... #Anemia #Differential
Summary of types of haemolytic anaemia. Visit gramproject.com for more medical diagrams, tables and flowcharts for
Summary of types of haemolytic ... anaemia. ... medical diagrams, tables ... diagnosis #clinical #management ... differential #algorithm #anaemia
Clinically Important Vitamins and Vitamin Deficiency States
Fat-soluble Vitamins: 
 • Vitamin A - Xerophthalmia, night blindness,
anaemia, ataxia ... Wernicke-Korsakoff syndrome ... paraesthesiae • Folate - Anaemia ... Vitamin B12 - Anaemia ... signs #symptoms #nutrition
Drugs Implicated in Hemolytic Anemia
 • Hapten (Drug binding to RBC membrane): Penicillin, Cephalosporin, Tetracycline, Tolbutamide,
Implicated in Hemolytic ... Anemia • Hapten ... #medications #Hemolytic ... #Anemia #differential ... #pharmacology #table
Micronutrient Deficiencies After Gastric Bypass
Fat-Soluble Vitamins:
 • Vitamin A - Night/complete blindness, xeropthalmia (pathologic dryness of
Folate - Macrocytic anemia ... B12 - Macrocytic anemia ... Minerals: • Iron - Anemia ... cognitive dysfunction, anemia ... #table #differential