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diagnosis differential oncology algorithm anemia intravascular leukemia management approach cirrhosis cll coagulation dic extravascular gap globulin hemolysis hemolytic hodgkins hps
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... for workup, including ... : Acute blood loss ... • Infections: Chronic ... Diagnosis #Algorithm #hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Diagnosis Algorithm Blood ... Disease • Marrow ... Non-lmmune #Anemia #Classification ... Diagnosis #Algorithm #Causes ... #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... anemia): - Disseminated ... e.g. lupus, CLL, lymphoma ... • Intrinsic RBC ... differential #diagnosis #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
cells can indicate disease ... Lymphocytosis: Absolute blood ... microglobulin Treatment ... Leukemia #diagnosis #workup ... #oncology #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Workup: • Full ... platelets - WBC ... number of sites of disease ... Treatment • Early ... #hematology #oncology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... ABO incompatible blood ... protein C and S Pathophysiology ... • Severe Liver Disease ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... -> AML: Blast crises ... develop leukostasis syndrome ... • Tumor lysis syndrome ... #Leukemia #Hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Marrow Failure • Chronic ... Myeloproliferative Disease ... Workup: • Complete ... #diagnosis #hematology
Hepatopulmonary Syndrome - Illness Script HPS is a pulmonary disorder of chronic liver disease characterized by a
Hepatopulmonary ... abnormalities PATHOPHYSIOLOGY ... arteriovenous shunting causes ... mixed blood to ... #diagnosis #hepatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... Amyloidosis • Lymphoma ... changes (POEMS syndrome ... gastric tumors • Hematology ... differential #diagnosis #hematology
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