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differential oncology algorithm anemia cirrhosis gammopathy hemolytic pbc treatment workup agglutinin alkaline alp aplastic cholangitis chronic classification cll coagulation cold
Suggested algorithm for follow-up of monoclonal gammopathy of undetermined significance (MGUS) Mayo Clinic Risk Stratification Model. CBC,
significance (MGUS ... CBC, complete blood ... #MGUS #Followup ... #algorithm #diagnosis ... #management #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Causes Intravascular ... usually IgM) (e.g. primary ... • Intrinsic RBC ... #diagnosis #hematology
Primary Biliary Cirrhosis - Diagnosis Algorithm Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort Signs: Jaundice, Xanthelasmata, Hepatomegaly Associated history:
Primary Biliary ... Algorithm Symptoms ... quadrant discomfort Signs ... #PBC #Primary ... #hepatology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
Summary Framework Hematologic ... constitutional symptoms ... cells < 10% • Urinary ... #Significance #hematology ... #diagnosis #oncology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Primary Biliary ... intralobular bile ducts causes ... Signs and Symptoms ... Diagnosis: • ... #hepatology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
15% of AIHA Primary ... Blood smear - RBC ... significance (MGUS ... the RBCs causing intravascular ... hemolytic #anemia #hematology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
- Differential Diagnosis ... Intestine - Other causes ... - Drugs - Primary ... (PBC) - Other ... #Algorithm #hepatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... pylori test (GI symptoms ... unclear, or if a primary ... hematologic disorder ... #hematology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
blasts and high WBC ... count cause hyperviscosity ... >100k, + lab signs ... Syndrome #TLS #diagnosis ... #management #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... Treatment: • Treat primary ... cause • Correct ... #Coagulation #diagnosis ... #management #hematology
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