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differential causes abnormal injury primary acute anemia antibodies approach arthritis associations autoantibodies chemistry cholangitis diseases disorders elevated enzymes gap globulin
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Algorithm for Transaminitis ... Ducts - PBC ... #Algorithm #diagnosis ... #hepatology #LiverFunctionTests
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Cirrhosis (PBC) ... Pathophysiology ... : • Viral hepatitis ... #Cirrhosis #PBC ... #workup #hepatology
Primary Biliary Cirrhosis - Diagnosis Algorithm Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort Signs: Jaundice, Xanthelasmata, Hepatomegaly Associated history:
Cirrhosis - Diagnosis ... #PBC #Primary ... #Biliary #Cirrhosis ... #Diagnosis #Algorithm ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
, PBC, PSC, IgG4 ... stone, Malignancy, PBC ... < 1 • Cirrhosis ... • LDH: Heart, RBC ... #algorithm #hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
- Differential Diagnosis ... , Acute biliary ... Malignancy, 1° PBC ... Causes #Acute #algorithm ... #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... • Cholestatic disease ... Duct Stone • Biliary ... • Others #LFTs ... #Hepatology #LiverEnzymes
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
• Bilirubin: RBC ... cardiac muscle, RBC ... • LDH: Heart, RBC ... #differential #Hepatology ... #transaminitis
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Dermatomyositis Anti-LKM (liver ... Anti-gp210 - Primary biliary ... cirrhosis (PBC) ... #diagnosis #table ... #rheumatology #
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
RBCs Decreased RBC ... Disease • Marrow ... Thalassemia • RBC ... Disorder • RBC ... #Hematology
Chronic Hepatitis B - Diagnosis and Management Algorithm • Who to treat: Essentially treat the pts with
Chronic Hepatitis ... • Monitor: CBC ... Chronic Hepatitis ... #Algorithm #Diagnosis ... Management #Treatment #Hepatology
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