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differential causes oncology leukemia lymphocytic testing approach arthritis blood et globulin hemeonc hemolytic hodgkins laboratory lymphoma markers platelet protein proteingap
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
- CD7, CD3 Chronic ... Pelger-Huet, Macrocytic anemia ... • Lymphoid (CLL ... bcr-able (+) ↑ WBC ... #hematology #Markers
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Artifact (redo CBC ... Autonomous: • Essential ... • Rheumatic disorders ... • Celiac disease ... #Hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
RBCs Decreased RBC ... • Anemia of Chronic ... Disease • Marrow ... #Classification ... #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
decreased PLT count: CBC ... changes), high MCV anemia ... gastric bypass), LFT ... , HBsAg/anti-HBc ... #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
hypertension • Unusual RBC ... acanthocytes - Consider RBC ... membrane disorder ... #Algorithm #workup ... #hematology #testing
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphocytosis on CBC ... cells can indicate disease ... • Neutropenia, anemia ... #workup #oncology ... #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
leukemia in adults • Disorder ... Vmphocytosis on routine CBC ... chemotherapy for low-risk disease ... Leukemia #oncology #hematology ... #management
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... autoimmune hepatitis, PBC ... gastric tumors • Hematology ... anemia • Other ... #hematology
Essential Thrombocythemia (ET) ET is a chronic myeloproliferative neoplasm. Most cases are related to mutations that affect
(ET) ET is a chronic ... : On the CBC, ... Thrombocythemia #ET #hematology ... #diagnosis #management ... #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... Hodgkin Lymphoma Workup ... platelets - WBC ... #hematology #oncology ... #management
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