21 results
Rouleaux formation is common in IgM gammopathy and may be particularly striking

Genevieve Crane, MD, PhD@evemariecrane

#Rouleaux #formation
Rouleaux formation ... evemariecrane #Rouleaux ... gammopathy #MGUS #Clinical ... #Pathology #Hematology
Plasma cell leukemia with extensive rouleaux formation. Aggressive disease & patients typically younger than other forms
with extensive rouleaux ... PlasmaCell #leukemia #rouleaux ... #formation #Clinical ... #Smear #Hematology ... #Pathology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Neutrophils - Low RBC ... Anemia RBCs in Rouleaux ... Myelodysplastic Syndromes ... Cells, Normal WBCs ... Algorithm #Causes #Hematology
A non-subtle example of true Sezary syndrome.  Patient presented with erythroderma without antecedent history of
of true Sezary syndrome ... mjcascio #Sezary #Syndrome ... #Cells #Clinical ... #Pathology #Smear ... #Microscopy #Hematology
Beautiful acanthocytes/spur cells in a patient with McLeod Syndrome. X-linked disorder characterized by reduced expression of
patient with McLeod Syndrome ... expression of Kell RBC ... SpurCells #McLeod #Syndrome ... #Smear #Pathology ... #Microscopy #Clinical
Autoagglutination should also be distinguished from “Rouleaux formation” wherein normal blood tends to form stacks on
distinguished from “Rouleaux ... #Clinical #Pathology ... Smear #Microscopy #Rouleaux ... #Formation #Hematology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... if high risk if WBC ... QD until normal WBC ... Differentiation #Syndrome ... #oncology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Aplastic Anemia Clinical ... Pancytopenia: • ↓ RBC ... • ↓ WBC • ↓ ... Aplastic #Anemia #oncology ... #hematology #diagnosis
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Gammopathy of Clinical ... capillary leak syndrome ... • Schnitzler syndrome ... Monoclonal #Gammopathy #Clinical ... #oncology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
capillary leak syndrome ... Hyperviscosity syndrome ... +Organomegaly+↑RBC ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology