15 results
liver algorithm anemia causes hemolysis testing abnormal arthritis atlas bloodcell chemistry chronic classification comparison disorders enzymes extravascular gap globulin hellp
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Agglutinin Disease ... Agglutinin Syndrome ... Diagnosis: • hemolytic ... Blood smear - RBC ... #hematology #diagnosis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
) (e.g. lupus, CLL ... agglutin disease ... • Intrinsic RBC ... Extravascular #Causes #differential ... #diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Agglutination - Cold ... agglutinins disease ... hypertension • Unusual RBC ... acanthocytes - Consider RBC ... #workup #hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Burr Cell RBC (Echinocyte ... Bite Cell RBC: G6PD ... Target Cell RBC ... #diagnosis #hematology ... #microscopy #atlas
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... 2) External (RBC ... Autoimmune: Warm AIHA, Cold ... 3) Internal (RBC ... Diagnosis #hematology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
, PBC, PSC, IgG4 ... • Bilirubin: RBC ... cardiac muscle, RBC ... • LDH: Heart, RBC ... #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
• Bilirubin: RBC ... cardiac muscle, RBC ... • LDH: Heart, RBC ... #differential # ... Hepatology #transaminitis
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
necrosis HELLP Syndrome ... #Pregnancy #hepatology ... #obstetrics #hepatitis ... #comparison #differential ... #diagnosis #icp
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... decreased PLT count: CBC ... gastric bypass), LFT ... , HBsAg/anti-HBc ... #Workup #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... Lymphocytosis on CBC ... cells can indicate disease ... #workup #oncology ... #hematology
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