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differential anemia management arterial coagulation dic embolism extravascular hemolysis hemolytic leukostasis lysis macrocytic macrocytosis thrombosis tls treatment tumor vascular venous
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Causes Intravascular ... anemia): - Disseminated ... • Intrinsic RBC ... #diagnosis #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Myelodysplastic Syndromes ... Cells, Normal WBCs ... #Macrocytosis #elevatedMCV ... #Algorithm #Causes ... #Hematology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
blasts and high WBC ... count cause hyperviscosity ... >100k, + lab signs ... #TLS #diagnosis ... #management #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... protein C and S Pathophysiology ... #Intravascular ... #Coagulation #diagnosis ... #management #hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
• Nephrotic Syndrome ... thrombocytopenia - Disseminated ... intravascular coagulation ... and other causes ... #hematology #differential
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