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diagnosis oncology intravascular extravascular hemolysis aplastic apml bandemia chronic classification coagulation dic differentiation disseminated gap globulin hemolytic hepatitis hodgkins hps
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... • Sickle cell ... elliptocytosis - RBC ... immune-complex hemolytic anemia ... #Causes #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
(HUS) • Other ... ) (e.g. lupus, CLL ... • Intrinsic RBC ... #differential # ... diagnosis #hematology
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Even with normal WBC ... relative to both WBC ... 21% had normal WBC ... #CBC #hematology ... #pathophysiology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Clinical Presentation ... Pancytopenia: • ↓ RBC ... • ↓ WBC • ↓ ... Treatment: ... #oncology #hematology
Hematology Algorithms Anemia is described as a reduction in the proportion of the red blood cells.
Hematology Algorithms ... RBC are produced ... Approximately 1% of RBC ... destruction of RBC ... Mentzer index = (MCV/RBC
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
C Clinical Presentation ... Lymphocytosis on CBC ... • Neutropenia, anemia ... microglobulin Treatment ... workup #oncology #hematology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Vascular Causes ... • Bilirubin: RBC ... cardiac muscle, RBC ... • LDH: Heart, RBC ... #hepatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Pathophysiology ... if high risk if WBC ... initiation • Differential ... QD until normal WBC ... #hematology #oncology
Hepatopulmonary Syndrome - Diagnosis and Management Summary A defect in arterial oxygenation due to a gas exchange
lung disease Caused ... shunt (Type 2) Clinical ... Arterial blood gas (ABC ... #management #treatment ... #hepatology
Hepatopulmonary Syndrome - Illness Script HPS is a pulmonary disorder of chronic liver disease characterized by a
abnormalities PATHOPHYSIOLOGY ... overperfusion + decreased RBC ... of orthodeoxia CLINICAL ... #Syndrome #cirrhosis ... #diagnosis #hepatology
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