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differential oncology causes aplastic atlas chronic gap hemolytic key lymphocytic management mds microcytic morphology myelodysplasia myelodysplastic protein proteingap rbc syndromes
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Myelodysplastic syndrome ... Bleeding gastric ulcer ... Thrombotic idiopathic thrombocytopenia ... Morphology #Atlas #key #diagnosis ... #differential #hematology
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... Algorithm Mean ... corpuscular (cell ... #Algorithm #Diagnosis ... #Workup #Hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
plaques, nodules, ulcers ... • Neutropenia, anemia ... , thrombocytopenia ... #diagnosis #workup ... #oncology #hematology
Skin Ulcers by Etiology - Differential Diagnosis Algorithm Physical: • Trauma • Pressure • Radiation Vascular: • Arterial
• Bleomycin Hematologic ... Anemia • Thalessemia ... #ulcerative #skinrash ... #dermatology #Differential ... #Diagnosis #Algorithm
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Megakaryopoiesis • Aplastic Anemia ... Leukemia, Tumour ... ITP • SLE • CLL ... Non-lmmune: • HELLP Syndrome ... #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Consider sickle cell ... Schistocytes, thrombocytopenia ... #Algorithm #workup ... #hematology #testing
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
virus (EBV) • Leukemia ... • ↓ WBC • ↓ ... antithymocyte globulin ... #oncology #hematology ... #diagnosis #management
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... common cytopenia: Macrocytic ... Cell Leukemia ... Workup: • Complete ... #diagnosis #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... changes (POEMS syndrome ... gastric tumors • Hematology ... anemia • Other ... #hematology
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