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management cll lymphocytic algorithm aplastic classification differentiation gap hemeonc hodgkins mds myelodysplasia myelodysplastic platelets protein proteingap syndromes thrombocytosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
• Neutropenia, anemia ... increase in gamma globulins ... microglobulin Treatment ... #diagnosis #workup ... #oncology #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... - infiltrates (anemia ... smear: Blasts APML ... #Leukemia #Hematology ... #Oncology #Diagnosis
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... for workup, including ... hemolysis, deficiency anemia ... • Infections: Chronic ... #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Pathophysiology ... initiation • Differential ... #APML #diagnosis ... #management #hematology ... #oncology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... 5) Symptoms of anemia ... to large cell lymphoma ... #oncology #hematology ... #hemeonc #diagnosis
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Marrow (Toxic injury ... virus (EBV) • Leukemia ... • ↓ WBC • ↓ ... Treatment: ... #oncology #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Workup: • Full ... platelets - WBC ... Immunohistochemical studies (to differentiate ... Treatment • Early ... #hematology #oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... changes (POEMS syndrome ... gastric tumors • Hematology ... : Lymphoma, Leukemia ... #diagnosis #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Marrow Failure • Chronic ... blood count with differential ... #diagnosis #hematology ... #oncology
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