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oncology algorithm classification hemolytic workup agglutinin approach cerebritis chronic cll cns cold elevatedmcv erythematosus extravascular hodgkins index intravascular leukemia lupus
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Blood Loss ... Decreased RBC ... Deficiency • Aplastic ... of Chronic Disease ... #Causes #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... lymphoproliferative disorders ... • Intrinsic RBC ... #differential # ... diagnosis #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Normal Blood Smear ... Neutrophils - Low RBC ... Myelodysplastic Syndromes ... #Causes #Hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
transform into a RBC ... RBC defects (e.g ... Production #Index #hematology ... #anemia #differential ... #diagnosis #calculation
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
decreased PLT count: CBC ... (CVID, WAS), (neurologic ... ), HBsAg/anti-HBc ... Diagnosis #Causes ... #Workup #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... Pancytopenia: • ↓ RBC ... • ↓ WBC • ↓ ... anemia Treatment ... #hematology #diagnosis
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Diagnosis: • hemolytic ... smear - RBC agglutination ... #hemolytic #anemia ... #hematology #diagnosis
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... Cerebrovascular Disease ... Erythematosus #SLE #CNS #neurology ... #rheumatology # ... #management #treatment
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Leukocyte reduced RBC ... Gamma-irradiated RBC ... Volume Reduced RBC ... • Washed RBC ... #management #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
caused by blood ... • Anemia • Aplastic ... Myeloproliferative Disease ... count with differential ... #diagnosis #hematology
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