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causes coagulation aptt blood bruising prolonged pt reactions algorithm cryofibrinogenemia disseminated hemostasis hodgkins lymphoma nonpalpable oncology palpable purpura transfusion transfusions
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Destruction • Abnormal ... Sequestration Disordered Platelet ... Iatrogenic) • Liver ... • Disseminated Intravascular ... #Causes #Hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... • Severe Liver ... #Coagulation #diagnosis ... causes #treatment #management ... #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Anticoagulants (Warfarin ... deficiency • Liver ... #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
of Hemostasis - Differential ... Diagnosis Framework ... Acquired: • Heparin ... , disseminated intravascular ... #Diagnosis #Hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Disseminated intravascular ... coagulation (DIC ... Prolonged #Causes #diagnosis ... #differential # ... hematology #coagulation
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... Supratherapeutic warfarin ... • Reduced liver ... amyloidosis #Abnormal ... hematology #coagulation
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
Paradoxical spontaneous bleeding ... Antiphospholipid syndrome • Warfarin-induced ... skin necrosis • DIC ... #rheumatology # ... hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
pain, dark urine, DIC ... maculopapular rash ... coagulopathy & ↑bleeding ... #Transfusions #diagnosis ... #management #hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
pain, dark urine, DIC ... maculopapular rash ... coagulopathy & ↑bleeding ... #Transfusion #diagnosis ... #management #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
genes and gene products ... - Low Hb and platelets ... Immunohistochemical studies (to differentiate ... #hematology #oncology ... #management
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