34 results
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
• Myopathy (Also ... Erythematosus #SLE #MSK ... #pathophysiology ... #signs #symptoms ... #diagnosis
Maculopapular - Diagnostic Algorithm
Pathophysiology:
- Catch-all term with a wide range of potential pathophysiologic mechanisms and causative
Maculopapular - Diagnostic ... : - Catch-all term ... Ill-appearing, vital sign ... Immunocompromised #Diagnosis ... Targetoid #Algorithm #Differential
Retinoblastoma: Pathogenesis and clinical findings
 • Sporadic mutation -> One allele of RB1 tumor suppressor gene
gene mutated in all ... / Symptoms / Complications ... Retinoblastoma #pathophysiology ... ophthalmology #diagnosis ... #signs #symptoms
Amyotrophic Lateral Sclerosis (ALS) Summary
ALS: combination of the clinical examination finding of amyotrophy with the pathologic
Lateral Sclerosis (ALS ... ) Summary ALS: combination ... lateral sclerosis Pathophysiology ... conditions listed in differential ... Treatment: - Multidisciplinary
Cauda Equina Syndrome
Causes:
 • Large lumbar degenerative disc herniation (central)
 • Severe lumbar spondylosis
 • Neoplasm
/ Symptoms / Complications ... CaudaEquina #Syndrome #MSK ... #pathophysiology ... #diagnosis #symptoms ... #signs
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... , AKI, acute limb ... WBC >100k, + lab signs ... Lysis Syndrome: • Pathophysiology ... #diagnosis #management
Tree in Bud Sign
The Tree-in-Bud sign represents Endobronchial spread in a linear branching pattern and centrilobular
Tree in Bud Sign ... actually seen in all ... #diagnosis #clinical ... #radiology #ChestCT ... #pathophysiology
Widened Pulse Pressure - Differential Diagnosis and Pathophysiology

Pulse pressure is the difference between the systolic blood
Diagnosis and Pathophysiology ... • Sepsis Complications ... • Mitchell et al ... #Diagnosis #Pathophysiology ... #causes #cardiology
Scapholunate Dissociation
The spacing between all carpal bones should be 1-2 mm, look for the "Terry Thomas"
spacing between all ... "Terry Thomas" sign ... spacing between all ... ("Terry Thomas sign ... Orthopedics #Sports #MSK
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
Rhabdomyolysis - Differential ... Diagnosis Framework ... 5X ULN • AST/ALT ... AST declines > ALT ... HAGMA • Late complication