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diagnosis differential symptoms hematology testing algorithm anemias arteritis arthritis autoantibodies chronic cll disease erythematosus gca giantcell hemolytic laboratory leukemia lupus
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
Hemolytic Anemias ... Algorithm Signs ... of anemia and hemolysis ... : • Autoimmune ... Hemolytic Anemias
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
autoimmune disease ... skin thickening Signs ... Scleroderma #SSc #rheumatology ... #diagnosis #signs ... symptoms #testing #workup
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... Lymphadenopathies 7% - Hemolytic ... anemia 4% - Myositis ... autoantibodies #signs ... #differential #rheumatology
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
signs/sx of inflammation ... complaints- anemia ... the “Chewing gum test ... them, but urgent rheumatology ... GCA #Temporal #Signs
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... affected joint • Systemic ... the presence of anemia ... #diagnosis #testing ... #Rheumatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
adults in the west ... Physical Exam/Signs ... • Neutropenia, anemia ... #workup #oncology ... #hematology
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
- Differential Diagnosis ... central nervous system ... Lack of UMN/LMN signs ... necrotizing myopathy • Autoimmune ... dystrophies Work
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Tests: • Measure ... Aldolase levels • EMG ... papules and Gottron sign ... ) • Shawl sign ... • Conduction system
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