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diagnosis hepatology differential management algorithm lfts transaminitis blood product reactions aclf aih alcoholic aortic arthritis ascites autoimmune cardiology chemistry cirrhosis
Causes of Severe Acute Liver Injury - Ichemic hepatitis - Acute biliary obstruction - Drug-Induced liver
Causes of Severe ... Acute Liver Injury ... - Drug-Induced liver ... injury - Viral ... #Hepatology #Diagnosis
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... months without treatment ... Injury (DILI) ... Viral Hepatitis ... #Chronic #Liver
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... Liver Injury - Differential ... #Injury #Differential ... #Diagnosis #Causes ... #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
non-essential drug/HDS treatments ... for alternative causes ... dechallenge • Acute ... hepatitis fibrosis ... #Algorithm #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... Injury Transaminase ... > 20x normal - Acute ... 5-10x normal - Chronic ... #Injury #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Cirrhosis • Chronic ... Viral Hepatitis ... Hepatopathy • Acute ... Viral Hepatitis ... injury) • Ischemic
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Algorithm Vascular Causes ... of Acute Liver ... > 3 • Chronic ... #injury #hepatitis
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
viral hepatitis ... viral hepatitis ... > 2 • NASH, Chronic ... > 3 • Chronic ... #differential #Hepatology
Causes of Severe Aortic Regurgitation - Differential Diagnosis Acute: • Leaflet: Traumatic Rupture, Acute Infective Endocarditis, Acute
Causes of Severe ... Dissection, Traumatic Injury ... to Root Chronic ... Rheumatic Fever, Whipple ... Systemic Arterial Hypertension
Portal Hypertension - Differential Diagnosis Portal Pressure = the pressure difference between the pressure in the portal
Portal Hypertension ... • Cirrhosis/acute ... hepatitis • Infiltrative ... sarcoidosis) • Liver ... #hepatology
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