23 results
Cancer agents and Electrolyte Disorders
 • Hypocalcemia: Cisplatin from Low Mg, Cetuximab- due to low Mg
Axitinib,
Cancer agents and ... Disorders • Hypocalcemia ... Trastuzumab • Hypokalemia ... Disorders #Cancer #agents ... chemotherapy #diagnosis #differential
Causes of Hypokalemia - Differential Diagnosis Algorithm
Once pseudohypokalemia is ruled out, causes of hypokalemia can be
Causes of Hypokalemia ... - Differential ... filling of bucket (low ... with the drain wide ... #Differential #
Causes of Hypokalemia - Differential Diagnosis Algorithm
Increased Loss 
 - Increased GI Loss
 - Increased Urinary
Causes of Hypokalemia ... - Differential ... #Differential # ... causes #potassium #low ... #pathophysiology
Potassium-Binding Agents to Treat Hyperkalemia
Sodium zirconium cyclosilicate (Lokelma):
 • Mechanism: Preferentially captures K in exchange for
Potassium-Binding Agents ... to Treat Hyperkalemia ... to 15 g QD • Side ... times daily • Side ... #medications #pharmacology
Causes of Hypocalcemia - Differential Diagnosis Algorithm
 • Extravascular: Pancreatitis, surgery, acute phosphate intake and renal
Causes of Hypocalcemia ... - Differential ... Hyperphosphatemia, Low ... Gadolinium contrast agents ... #Differential #
Distal Renal Tubular Acidosis
Distal RTA is the true Nephrogenic RTA and can be truly divided into
variants- the hypokalemic ... intercalated cells - A Low ... mutations) - CNI agents ... Trimethoprim • Low ... RTA #diagnosis #differential
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
of Drug-Induced Hyperkalemia ... MunerMohamed1 #hyperkalemia ... #differential # ... diagnosis #pathophysiology ... #pharmacology #
NSAID Selectivity Spectrum
COX-2 Selective NSAID - Celecoxib
 • Increased risk for CV events
 • Decreased risk
Increased risk for CV events ... Decreased risk for Gl side ... Decreased risk for CV events ... Cardioprotective at low ... selectivity #spectrum #pharmacology
Metformin Pharmacology Summary
Mechanisms of Action:
 • Suppresses gluconeogenesis by the liver
 • Increases insulin-mediated glucose utilization
Metformin Pharmacology ... effective oral agent ... hypoglycemia • Low ... — mitigated by slow ... #Metformin #Pharmacology
Digoxin Pharmacology and Pathophysiology
1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
Digoxin Pharmacology ... and Pathophysiology ... - Hyperkalemia ( ... (or low potassium ... #Pathophysiology