9 results
Sulfonylureas - Pharmacology Summary
Mechanisms of Action: Binds to the ATP-sensitive potassium channel in pancreatic beta cells,
Sulfonylureas - Pharmacology ... in CKD Common Side ... Sulfonylureas #Pharmacology ... DM2 #diabetes #endocrinology
Metformin Pharmacology Summary
Mechanisms of Action:
 • Suppresses gluconeogenesis by the liver
 • Increases insulin-mediated glucose utilization
Metformin Pharmacology ... disease Common Side ... Toxicities: • GI side ... #Metformin #Pharmacology ... DM2 #diabetes #endocrinology
GLP-1 Receptor Agonists - Pharmacology Summary
Mechanisms of Action: Stimulate glucose-dependent insulin release from the pancreas (GLP-1
Receptor Agonists - Pharmacology ... pancreatitis Common Side ... Toxicities: • Gl side ... Receptor #Agonists #Pharmacology ... DM2 #diabetes #endocrinology
SGLT2 Inhibitors 
SGLT2 inhibitors are the newest class of anti-diabetic medications, with the first one (Canagliflozin)
drugs include side ... Side effects include ... SGLT2 #Inhibitors #Pharmacology ... DM2 #Diabetes #Endocrinology
SGLT2 Inhibitors - Pharmacology Summary
Mechanisms of Action: Inhibits SGLT2 (sodium/glucose cotransporter 2) in the proximal tubule,
SGLT2 Inhibitors - Pharmacology ... of use) Common Side ... SGLT2 #Inhibitors #Pharmacology ... DM2 #diabetes #endocrinology
DPP-4 Inhibitors - Pharmacology Summary
Mechanisms of Action: Inhibits DPP-4 (dipeptidyl peptidase 4), which normally inactivates GLP-1
4 Inhibitors - Pharmacology ... failure Common Side ... DPP4 #Inhibitors #Pharmacology ... DM2 #diabetes #endocrinology
DPP4 Inhibitors - Normal and Renal Dosing

Increase Incretins (GLP-I & GIP) -> Stimulates Insulin, Inhibits Glucagon
with only few side ... Renal #Dosing #Pharmacology ... Diabetes #DM2 #Endocrinology
GLP-1 Agonists

Adlyxin (Lixisenatide) Daily
Bydureon (Exenatide ER) Weekly 
Ozempic (Semaglutide) Weekly 
Trulicity (Dulaglutide) Weekly 
Victoza (Liraglutide) Daily
Common side effects ... GLP1 #Agonists #Pharmacology ... Diabetes #DM2 #Endocrinology
Rybelsus (oral semaglutide) - First Oral GLP-1 Agonist
Dosing:
3 mg daily x 30 days, then 7 mg
GI upset as a side ... minimize this side ... semaglutide #Diabetes #Pharmacology ... #Endocrinology