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diagnosis management erythematosus systemic hematology workup activation ana antinuclear arthritis autoantibodies chronic classification cll differential disease gravis hiv laboratory leukemia
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... Initial screening test ... severe disease Treatment ... #Systemic #Lupus ... Summary #diagnosis #rheumatology
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... and Systemic lupus ... clinically suspected, tests ... overlap syndromes ... erythematosus #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Classification: • Acute ... Non-autoimmune rheumatologic ... Pleural effusions • Acute ... 1, SCL-70, RNP antibodies
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
rheumatoid arthritis, SLE ... Bedside: ice pack test ... /Edrophonium test ... - LRP4 antibodies ... aspiration and acute
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... joint • Systemic lupus ... double-stranded DNA antibodies ... for Acute Polyarthritis ... diagnosis #testing #Rheumatology
Acute Retroviral Syndrome Acute Retroviral Syndrome is the symptomatic presentation of acute human immunodeficiency virus infection •
Syndrome Acute ... • New onset SLE ... after exposure • Antibodies ... HIV-1 or HIV-2 antibodies ... ) Treatment:
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
SJIA], systemic lupus ... erythematosus [SLE ... Liver function tests ... Treatment: • Corticosteroids ... #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
such as systemic lupus ... retinopathy Lab Tests ... C-ANCA) pattern: antibodies ... vasculitis, and SLE ... differential #diagnosis #rheumatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
non-Hodgkin lymphoma SLL ... adults in the west ... microglobulin Treatment ... • Richter’s Syndrome ... ’s lymphoma or acute
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
cases such as: • SLE ... Diagnosis: • Clinical tests ... Anti-Matrilin-1 Ab ○ Antibodies ... affected tissue Treatment ... Polychondritis #rheumatology
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