11 results
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
Lupus Nephritis, Cryoglobulinemia ... (C-ANCA): GPA > ... >> MPA > eGPA • ... ): eGPA, MPA >>> ... Glomerulonephritis #Vasculitis
Granulomatosis with Polyangiitis (GPA) and Microscopic Polyangiitis (MPA) - ANCA Vasculitis Management Algorithm - ACR/VF 2021
Polyangiitis (GPA ... ) - ANCA Vasculitis ... #Polyangiitis #GPA ... #ANCA #Vasculitis ... Guidelines #algorithm #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
capillaritis • EGPA ... > PR3 60% • GPA ... vesicular eruption - Joints ... (Dx: GPA, EGPA, ... differential #diagnosis #rheumatology
Vasculitis Involving the Skin - Differential Diagnosis Framework

Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis
Secondary: CTD: SLE, RA
Urticarial/LCV) - Cryoglobulinemic ... ANCA Associated: ... polyangiitis - EGPA ... - GPA Cutaneous ... #dermatology #rheumatology
Hemoptysis - Differential Diagnosis Framework
Massive Hemoptysis: >150-300 mL in 24h
Airway disease: 
 • Bronchitis, Bronchiectasis, Malignancy
Kaposi's sarcoma • Rheumatologic ... / Autoimmune: ANCA-Assoc ... vasculitis (GPA ... > EGPA, MPA), Cryoglobulinemia
Eosinophilic Granulomatosis with Polyangiitis (EGPA) - ANCA Vasculitis Management Algorithm - ACR/VF 2021 Guidelines
 • Active
Polyangiitis (EGPA ... ) - ANCA Vasculitis ... @MithuRheum #EGPA ... #Vasculitis #Management ... Guidelines #algorithm #rheumatology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Cryoglobulinemia ... DDX: • ANCA (Antineutrophil ... - GPA, EGPA, microscopic ... classification #rheumatology ... #vasculitis
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Polyangiitis (GPA ... polyangiitis (GPA ... GPA causes disease ... polyangiitis • EGPA ... #Polyangiitis #GPA
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
/HSP • Cryoglobulinemia ... (MIXED) • ANCA ... - GPA - EGPA ... Differential #Diagnosis #hematology ... #rheumatology #
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
progressive) EGPA ... MPO > PR3 60/ GPA ... Palpable purpura, joint ... + MPO) Cryoglobulinemic ... Differential #Diagnosis #Rheumatology