18 results
Clinical Examination for Liver and Biliary Diseases
1) Hands: Clubbing, Dupuytren's contracture, Leuconychia, Bruising, Flapping tremor (hepatic
and Biliary Diseases ... 1) Hands: Clubbing ... fluid, Dilated abdominal ... Ascites, Palpable gallbladder ... disease #signs #diagnosis
Jaundice - Differential Diagnosis Algorithm
Pre-Hepatic - Unconjugated Hyperbilirubinemia
Increased Production
 • Hemolysis
 • Ineffective Erythropoiesis
 • Hematoma
Decreased
- Differential Diagnosis ... Crigler-Najjar Syndromes (l and ... Dilatation on Ultrasound ... Gallstones • Biliary ... Cholangiocarcinoma • Primary
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
DILI) - Stepwise Diagnosis ... disease, Hepatic ... biliary cholangitis ... , Primary sclerosing ... #Injury #Diagnosis
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Primary Biliary ... 65 years PBC Pathophysiology ... cholestasis → Cirrhosis/Liver ... or higher • Liver ... malignancies, Hepatic
Portal Hypertension - Differential Diagnosis
Portal Pressure = the pressure difference between the pressure in the portal
- Differential Diagnosis ... sarcoidosis) • Liver ... pregnancy • Primary ... biliary cirrhosis ... #Differential #Diagnosis
The 6 C’s of Primary Sclerosing Cholangitis (PSC)
PSC is a chronic, cholestatic, immune-mediated disease characterized by
The 6 C’s of Primary ... extra-hepatic bile ... to multi-focal biliary ... hepato-biliary ... gallbladder cancer
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
- Differential Diagnosis ... Pruritis History and ... elevation DDX of Hepatic ... - Drugs - Primary ... biliary Cholangitis
Schematic representation of the major sources of ammonia production and its excretory pathway (GI = gastrointestinal,
decompensated liver ... = Non hepatic ... syndrome (Peds) - Primary ... deficiency #Ammonia #Pathophysiology ... #Differential #Diagnosis
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... nausea, vomiting, abdominal ... Antithrombin Ill • Ultrasound ... ) Differential Diagnosis ... age • Monitor and
Systemic Sclerosis (Scleroderma)
Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs
3
by vasculopathy and ... distal to elbows/wrists ... pericarditis • Hepatic ... : PBC (primary biliary ... #rheumatology #diagnosis