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diagnosis erythematosus management sle classification signs symptoms syndrome activation differential eularacr hematology macrophage mas sarcoidosis sjogrens vasculitides vasculitis
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... Criteria for Systemic ... Clinical Domains ... hemolysis • Renal ... #diagnosis #rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... of Systemic Lupus ... (SLE) General: ... in small joints Nervous ... symptoms #diagnosis #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
lupus erythematosus ... lymphadenopathy • Central ... nervous system ... Histopathologic criteria ... #Rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... ) Suspect: Clinical ... Erythematous, macular ... , and elevated serum ... artery or vein
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
inflammation Others: • Lupus ... gastrointestinal, and/or central ... nervous system ... lupus erythematosus ... differential #diagnosis #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
gland) biopsy • Ocular ... salivary ducts Clinical ... Involvement: • Central ... nervous system ... phenomenon (16%) MSK
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
the lymphatic system ... failure Clinical ... General: fever, ... skin (16-32%): lupus ... anterior/posterior MSK
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