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management lupus hematology sle summary syndrome aflp arteritis coagulation comparison dermatology dic disseminated erythematosus fatty gca giantcell hemophagocytic hepatology hlh
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... 40, F:M 9:1 • Clinical ... Lupusreference #druginduced ... comparison #table #rheumatology ... #diagnosis #management
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Fatty Liver of Pregnancy ... : • Defect in fetal ... = nonspecific (nausea ... rapidly develops (DIC ... ) Differential Diagnosis
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
organ damage Clinical ... + Bleeding Treatment ... Treat primary cause ... #Coagulation #diagnosis ... #causes #treatment
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Erythematosus (SLE) - Diagnosis ... 40, F:M 9:1 • Clinical ... of SLE versus DIL ... life-threatening • Treatment ... Management #Summary #rheumatology
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
to 1:1 F:M • Clinical ... Discontinuation of causal ... Lupusreference #DrugInduced ... #Lupus #DIL #rheumatology ... #diagnosis #treatment
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Assessment • Clinical ... Fibrinogen level, ↑ sIL ... Treatment: • ... #summary #rheumatology
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
Diagnosis = clinical ... or sed rate): Value ... GCA, but normal values ... Treatment of GCA ... them, but urgent rheumatology
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
Rheumatic pain Clinical ... : • A clinical ... out other causes ... and lower jaw Treatment ... SAPHO #Syndrome #Rheumatology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Out Secondary Causes ... Exposure to heavy metal ... with isolated del ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... salivary ducts Clinical ... • Nephrogenic DI ... Adenocarcinoma Treatment ... Sjogrens #Syndrome #Rheumatology
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