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diagnosis algorithm causes arterial classification dili elevation embolism gastroenterology hematology idiosyncratic induced injury lactate lactic liverenzymes management pathophysiology thrombosis typea
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Chronic - ongoing ↑ LFTs ... disease 6-9 mo ... Calculate R-Value ... Idiosyncratic #differential ... gastroenterology #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... • Wilson's • Pregnancy ... • Cholestatic disease ... • Others #LFTs ... #Hepatology #LiverEnzymes
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Myeloproliferative disease ... • Intravenous Drug ... Use • Pregnancy ... • Drugs: - ... Syndrome, Ischemic Liver
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
- Differential ... to bolus these values ... presentations and disease ... circulation If drugs ... #Elevation #Differential
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