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diagnosis management rheumatology nephrology algorithm chronic crisis differential erythematosus fatigue gca giantcell hemeonc hemophagocytic hepatology hepatorenal hlh hrs lupus lymphohistiocytosis
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Neoplastic / Hematologic ... • Anemia • ... • Rheumatoid Arthritis ... • Drug Abuse (e.g ... Chronic Fatigue Syndrome
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... juvenile idiopathic arthritis ... underlying disease (eg ... • Infection (eg ... with leukopenia, anemia
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
with systemic, neurologic ... not be subtle e.g ... E.g. 80 yo ESR cutoff ... systemic complaints- anemia ... identifies 85 to 95% of cases
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
• Malignancy (e.g ... Endocrine disorders (e.g ... vein thrombosis Hematologic ... lymphopenia, low PLT • Anemia ... Chronic B-cell activation
Scleroderma Renal Crisis (SRC) Clinical Presentation of Scleroderma Renal Crisis: 1) Acute kidney injury 2) Abrupt onset of hypertension 3)
microangiopathic hemolytic anemia ... endothelial cell activation ... onion-skinning" of arteries ... other pathology (e.g ... (short-acting, e.g
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
caused by uncontrolled ... ▪ Infections (e.g ... pro-inflammatory cytokines (e.g ... Immunosuppression (e.g ... anti-IFN-γ antibodies (e.g
Hepatorenal Syndrome (HRS) Definition: • Functional, potentially reversible kidney impairment. • Occurs in advanced liver disease: cirrhosis, severe alcoholic
Hepatorenal Syndrome ... sympathetic + ADH activation ... Exclude other AKI causes ... liver insult (e.g ... #Hepatology #Nephrology
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