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diagnosis hematology differential neurology algorithm workup anesthesia anesthesiology checklist pulmonary barre cardiomyopathy classification endocarditis guillain intraoperative lung lysis mds myelodysplastic
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... old, ~10,000 new cases ... cytopenias (usually anemia ... #treatment #hematology ... #oncology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Megakaryopoiesis • Aplastic Anemia ... Toxic Damage (e.g ... Displacement (e.g ... Non-lmmune: • HELLP Syndrome ... Foreign Surface (e.g
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
(usually IgG) (e.g ... (usually IgM) (e.g ... deficiencies (e.g ... Hemoglobinopathies (e.g ... Membrane defects (e.g
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... malignancies • Anemia ... inflammatory disorders (e.g ... Myelodysplastic syndrome ... #hematology #secondary
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Increased Requirement (e.g ... Myelodysplastic Syndromes ... Diagnosis #Algorithm #Causes ... #Hematology
Acquired von Willebrand Syndrome - Diagnosis and Management • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
von Willebrand Syndrome ... Diagnosis and Management ... Lymphoproliferative disorders (e.g ... Myeloproliferative disorders (e.g ... #treatment #hematology
Syncope is a sudden, transient loss of consciousness, which is thought to be secondary to cerebral
cardiac syncope, e.g ... carotid sinus syndrome ... further guide management ... and an initial ECG ... The treatment strategy
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... and petechiae Causes ... Treatment: ... #oncology #hematology ... #diagnosis #management
Peri-operative Hyperthermia - Guidelines for Crises in Anaesthesia If prolonged or ≥ 39 C this is a
Treatment depends ... Surgical devices, e.g ... Sepsis (→ 3-14) e.g ... (e.g. haloperidol ... Checklist #Diagnosis #Management
Tumor Lysis Syndrome An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... malignancies Treatments ... with Ca only if EKG ... #TLS #oncology ... #management #UricAcid
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