22 results
Causes of Neuromuscular Weakness
 • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Weakness • Spinal ... Motor Nerves: ALS ... Syndrome, Myasthenia Gravis ... #Causes #differential ... #diagnosis #neurology
Myasthenia Gravis Overview

Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction.  Ab to
life-threatening Differential ... Myotonic dystrophy - Brain ... Generalized fatigue - ALS ... Serologic and EMG ... diagnosis #management #neurology
Generalized Weakness - Differential Diagnosis Framework
"l feel weak":
 • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis
 •
Generalized Weakness ... - Differential ... Polyneuropathy, ALS ... Diagnosis #causes ... #neurology
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
Weakness - Differential ... nervous system: Brain ... • Infectious: Brain ... Postsynaptic: Myasthenia Gravis ... Diagnosis #neurology
Ocular Myasthenia Gravis on Physical Exam

A 41yo female was referred by her neurologist for double vision.
Her clinical exam ... non-localized EOM weakness ... suspected and anti-ACh ... #PhysicalExam #clinical ... ophthalmology #neurology
Myasthenia Gravis - Summary
 • an autoimmune disease of the postsynaptic neuromuscular junction associated with antibodies
Myasthenia Gravis ... Diagnosis: • Based on clinical ... More likely to cause ... #Myasthenia #Gravis ... diagnosis #management #neurology
Amyotrophic Lateral Sclerosis (ALS) Summary
ALS: combination of the clinical examination finding of amyotrophy with the pathologic
- Causes progressive ... EMG: LMN Signs in ... MRI: Brain, cervical ... conditions listed in differential ... Lateral #Sclerosis #neurology
Imaging Patterns of Toxic and Metabolic Brain Disorders

Thalami, Mammillary Bodies and Tectum: Wernicke Encephalopathy
Dentate Nuclei: Metronidazole,
and Metabolic Brain ... #Disorders #Clinical ... #Differential # ... Diagnosis #Radiology ... #Neurology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE) Clinical ... autoantibodies that will cause ... thrombosis and/or blood-brain ... (for secondary APS ... Erythematosus #SLE #CNS #neurology
Guillain-Barre Syndrome - Summary

Acute AIDP that presents with rapidly progressive flaccid weakness

Epidemiology:
 • 1-2 cases/100,000 per
Epidemiology: • 1-2 cases ... meningococcal, H1N1) Clinical ... complete paralysis of all ... Guillain-Barre Clinical ... management #treatment #neurology