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diagnosis hematology management hodgkins apml cd4 classification dermatologic dermatology differentiation globulin gpa granulomatosis icl idiopathic leukemia lymphocytopenia lymphopenia mds monoclonal
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
- Comparison ... #NonHodgkins #comparison ... #oncology #diagnosis ... #differential # ... hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
activity • ↓ LAP ... : Blast crises ... develop leukostasis syndrome ... • Tumor lysis syndrome ... #Oncology #Diagnosis
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
accounts for 10% of all ... Immunohistochemical studies (to differentiate ... Treatment • Early ... classification #hematology ... #oncology #management
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Marginal Zone Lymphoma ... Marginal zone lymphoma ... Pseudohyponatremia • ↓anion gap ... #Monoclonal #Differential ... #Diagnosis #Oncology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA causes disease ... reticularis Differential ... • Goodpasture syndrome ... • Angiocentric lymphoma ... rash #diagnosis #rheumatology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Out Secondary Causes ... factor (GCSF) treatments ... blood count with differential ... #diagnosis #hematology ... #oncology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Incidence: common in APL ... Triggers: ATRA treatment ... initiation • Differential ... #oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Amyloidosis • Lymphoma ... changes (POEMS syndrome ... Castleman disease • AL ... : Lymphoma, Leukemia ... #ProteinGap #differential
Idiopathic CD4 Lymphopenia (ICL) / Lymphocytopenia DIAGNOSTIC CRITERIA FOR ICL • Persistent CD4 T-cell lymphopenia •
chemotherapy) • Genetic syndromes ... Unc119) • Heme (lymphoma ... #diagnosis #hematology ... #Differential # ... Causes #lymphocytopenia
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
Males • Affects all ... Viral infection • Lymphoma ... • GPA/EGPA • ... affected tissue Treatment ... Polychondritis #rheumatology
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